last updated:
最近の主な研究業績
- Single-molecule analysis of intracellular insulin granule behavior and its application to
analyzing cytoskeletal dependence and pathophysiological implications.
Hatakeyama H, Oshima T, Ono S, Morimoto Y, Takahashi N.
Frontiers in Physiology 2023 14:1287275. 論文へのリンク - Effects of Roxadustat on Erythropoietin Production in the Rat Body.
Yasuoka Y, Izumi Y, Fukuyama T, Omiya H, Pham TD, Inoue H, Oshima T, Yamazaki T, Uematsu T, Kobayashi N, Shimada Y, Nagaba Y, Yamashita T, Mukoyama M, Sato Y, Wall SM, Sands JM, Takahashi N, Kawahara K, Nonoguchi H.
Molecules 2022 Feb 8;27(3):1119. 論文へのリンク - Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis.
Ucar H, Watanabe S, Noguchi J, Morimoto Y, Iino Y, Yagishita S, Takahashi N, Kasai H.
Nature 2021 Dec 23;600(7890):686-689. 論文へのリンク - Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver.
Yasuoka Y, Izumi Y, Fukuyama T, Inoue H, Oshima T, Yamazaki T, Uematsu T, Kobayashi N, Shimada Y, Nagaba Y, Mukoyama M, Sato Y, Sands JM, Kawahara K, Nonoguchi H.
Molecules 2021 Sep 5;26(17):5399. 論文へのリンク - MEK/ERK signaling in β-Cells bifunctionally regulates β-Cell mass and glucose-stimulated insulin secretion response to maintain glucose homeostasis.
Matsumoto-Ikushima Y, Awazawa M, Kobayashi N, Osonoi S, Takemiya S, Kobayashi H, Suwanai H, Morimoto Y, Soeda K, Adachi J, Muratani M, Charron J, Mizukami H, Takahashi N, Ueki K.
Diabetes 2021 July;70:1519-1535. 論文へのリンク - Regulation of Rhcg, an ammonia transporter, by aldosterone in the kidney.
Eguchi K, Izumi Y, Yasuoka Y, Nakagawa T, Ono M, Maruyama K, Matsuo N, Hiramatsu A, Inoue H, Nakayama Y, Nonoguchi H, Lee HW, Weiner ID, Kakizoe Y, Kuwabara T, Mukoyama M.
J Endocrinol. 2021 May;249(2):95-112. 論文へのリンク - Melanophilin Accelerates Insulin Granule Fusion without Predocking to the Plasma Membrane.
Wang H, Mizuno K, Takahashi N, Kobayashi E, Shirakawa J, Terauchi Y, Kasai H, Okunishi K, Izumi T.
Diabetes 2020 Dec;69(12):2655-2666. 論文へのリンク - TRPA1 and TRPV1 channels participate in atmospheric-pressure plasma-induced [Ca2+]i response.
Kawase M, Chen W, Kawaguchi K, Nyasha MR, Sasaki S, Hatakeyama H, Kaneko T, Kanzaki M.
Sci Rep 2020 Jun 16;10(1):9687. 論文へのリンク - Cooperative actions of Tbc1d1 and AS160/Tbc1d4 in GLUT4-trafficking activities.
Hatakeyama H, Morino T, Ishii T, Kanzaki M.
J Biol Chem 2019 Jan 25;294(4):1161-1172. 論文へのリンク - Strong stimulation triggers full fusion exocytosis and very slow endocytosis of the small dense core granules in carotid glomus cells.
Tse A, Lee AK, Takahashi N, Gong A, Kasai H, Tse FW.
J Neurogenet 2018 Sep;32(3):267-278. 論文へのリンク - Fludrocortisone stimulates erythropoietin production in the intercalated cells of the collecting ducts.
Yasuoka Y, Izumi Y, Nagai T, Fukuyama T, Nakayama Y, Inoue H, Horikawa K, Kimura M, Nanami M, Yanagita K, Oshima T, Yamazaki T, Uematsu T, Yamamura R, Kobayashi N, Shimada Y, Nagaba Y, Nakanishi T, Yamashita T, Mukoyama M, Sato Y, Kawahara K, Nonoguchi H.
Biochem Biophys Res Commun 2018 Sep 18;503(4):3121-3127. 論文へのリンク - Heterotypic endosomal fusion as an initial trigger for insulin-induced glucose transporter 4 (GLUT4) translocation in skeletal muscle.
Hatakeyama H, Kanzaki M.
J Physiol 2017 Aug 15; 595(16):5603-5621. 論文へのリンク - Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and beta cells.
Takahashi N, Sawada W, Noguchi J, Watanabe S, Ucar H, Hayashi-Takagi A, Yagishita S, Ohno M, Tokumaru H, Kasai H.
Nat Commun 2015 Oct 6;6:8531. 論文へのリンク - SNARE conformational changes that prepare vesicles for exocytosis.
Takahashi N, Hatakeyama H, Okado H, Noguchi J, Ohno M, Kasai H.
Cell Metab 2010 Jul 7;12(1):19-29. 論文へのリンク - Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse beta-cells.
Hatakeyama H, Takahashi N, Kishimoto T, Nemoto T, Kasai H.
J Physiol 2007 Aug 1;582(Pt 3):1087-98. 論文へのリンク - Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets.
Hatakeyama H, Kishimoto T, Nemoto T, Kasai H, Takahashi N.
J Physiol 2006 Jan 15;570(Pt 2):271-82. 論文へのリンク - Sequential exocytosis of insulin granules is associated with redistribution of SNAP25.
Takahashi N, Hatakeyama H, Okado H, Miwa A, Kishimoto T, Kojima T, Abe T, Kasai H.
J Cell Biol 2004 Apr 26;165(2):255-62. 論文へのリンク - Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet.
Takahashi N, Kishimoto T, Nemoto T, Kadowaki T, Kasai H.
Science 2002 Aug 23;297(5585):1349-52. 論文へのリンク - Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells.
Takahashi N, Kadowaki T, Yazaki Y, Ellis-Davies GC, Miyashita Y, Kasai H.
Proc Natl Acad Sci U S A 1999 Jan 19;96(2):760-5. 論文へのリンク - Multiple exocytotic pathways in pancreatic beta cells.
Takahashi N, Kadowaki T, Yazaki Y, Miyashita Y, Kasai H.
J Cell Biol 1997 Jul 14;138(1):55-64. 論文へのリンク