北里大学医学部薬理学
大学院医療系研究科分子薬理学
Department of Pharmacology, Kitasato University School of Medicine
Department of Molecular Pharmacology, Graduate School of Medical Science Kitasato University

〒252-0374 神奈川県相模原市南区北里1-15-1
TEL: 042-778-9113 FAX: 042-778-9114
1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan
Phone: +81-42-778-9113 FAX: +81-42-778-9114

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更新日 2019-01-21 | 作成日 2010-01-14

招待講演会

2016年 3月7日
The collecting lymphatic vasculature: regulation and roles in pathophysiology
Gwen Randolph教授
Washington University School of Medicine

2016年 3月7日
TGF-β regulates blood- and lymph- angiogenesis and promotes tumor metastasis
Fumiko Ito准教授
Tokyo U. Pharmacy & Life Sciences

2016年 3月7日
Roles of TGF-β family signals during the formation and maintenance of vascular systems
Tetsuro Watabe教授
Tokyo Med. Dent. Univ.

2016年 3月7日
Semaphorin/Plexin signaling pathway in lymphatic vascular patterning
Masanori Hirashima准教授
Kobe University Sch. Med.

2015年 9月28日
Angiogenesis in cancer - general pathways and their therapeutic implications
Valentin Djonov 教授
Institute of Anatomy, University of Bern, Switzerland

2015年 9月28日
Vascular normalization as an emerging strategy to enhance cancer immunotherapy
Dai Fukumura 教授
Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, USA

2015年 9月28日
Biomedical significances of Tie2 activation for pathologic vasculatures
Gou Young Koh 教授
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Korea

2015年 9月28日
Endothelial cell metabolism in normal and diseased vasculature
Peter Carmeliet 教授
Laboratory of Angiogenesis & Neurovascular link, Vesalius Research Center, Belgium

2015年 9月28日
MicroRNA regulation of adult lymphangiogenesis
Calvin Kuo 教授
Department of Medicine, Stanford University School of Medicine, USA

2015年 8月20日
Endothelial mutagenesis reveals key regulatory pathways that maintain vascular homeostasis
Luisa Iruela-Arispe 教授
Department of Molecular, Cell and Devision Biology, UCLA, USA

2015年 2月13日
The family of secreted phospholipase A2: from toxic to therapeutic enzymes
Gerard Lambea 教授
Institute of Molecular and Cellular Pharmacology, CNRS and University of Nice Sophia, Antipolis, France

2014年 4月18日
An important role of lymphatic endothelium in cancer progression and metastasis
Michael Detmar 教授
Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland

2014年 4月18日
Overcoming tumor resistance to VEGF blockade by co-targeting ANG2/TIE2 signaling and macrophages
Michele De Palma 教授
The Swiss Institute for Experimental Cancer Research (ISREC), school of Life Sciences, Swiss Federale Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

2014年 4月18日
Tumor-associated lymphangiogenesis promotes pro-invasive and immune suppressive stromal remodeling
Melody A. Swartz 教授
Institute of Bioengineering and Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

2014年 4月18日
Surprising features of lymphatic vessels learned from a model of pulmonary lymphoangiectasia
Donald M. McDonald 教授
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California SanFrancisco (UCSF), CA, USA

2014年 4月18日
Angiocrine signaling in tissue regeneration and tumor progression
Hellmut G. Augustin 教授
Vascular Biology, Medical Faculty Mannheim, Heidelberg University (CBTM), and German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Germany

2014年 4月18日
Molecular parallels between neural and vascular development
Anne Eichmann 教授
Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA

2014年 4月18日
Prox1-Vegfr3 feedback loop maintains the identity of lymphatic endothelial cell progenitors
Guillermo Oliver 教授
St. Jude Children's Research Hospital, TN, USA

2014年 3月24日
Role of the microenvironment in the regulation of tumor angiogenesis
Napoleone Ferrara 教授
University of California San Diego (UCSD), La Jolla, CA, USA

2014年 2月24日
VEGF-regulated vascular permeability: Molecular mechanisms and contribution to disease
Lena Claesson-Welsh 教授
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

2013年11月16日
血管新生における分子機序の解明とその応用
高倉 信幸 教授
大阪大学 微生物病研究所 環境応答研究部門 情報伝達分野

2013年3月19日
Tumor-associated lymphatic vessels: More than an escape route
Melody A. Swartz 教授
Institute of Bioengineering and Cancer Research, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland

2013年 2月6日
Branch or expand? Endothelial cell dynamics regulating vascular patterning
Holger Gerhardt 教授
Vascular Biology Laboratory, London Research institute, Cancer Research, UK

2012年10月30日
Lymphatic endothelium - a critical modulator of tumor progression and metastasis
Michael Detmar 教授
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland

2012年 9月28日
Molecular regulation of angiogenesis and vessel wall assembly
Ralf H. Adams 教授
Department of Tissue Morphogenesis, Max-Planck-Institute for Molecular Biomedicine, and Faculty of Medicine

2012年 7月 3日
Angiogenesis and Lymphoangiogenesis in Mouse Airways
Peter Baluk 先生
Cardiovascular Research Institute, University of California SanFrancisco

2012年 6月 8日
Pericytes - The Unknown Neighbor of the Endothelium
Christer Betsholtz 教授
Karolinska Institutet, Stockholm, Sweden

2012年 3月12日
Lymphoangiogenesis: The Plasticity of Lymphatics in Disease
Donald M. McDonald 教授
Department of Anatomy, University of California SanFrancisco

2011年12月26日
Monocyte and Macrophage Diversity Promotes Tumor Progression and Metastasis
Jeffrey W. Pollard 教授
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine

2011年11月11日
オートタキシン-LPAシグナリングによる血管形成制御
青木 淳賢 教授
東北大学大学院 薬学研究科 分子細胞生化学

2011年10月17日
Critical Regulators for Tumor Angiogenesis and Lymphatic Niche
Gou Young Koh 教授
Laboratory of Vascular Biology and Stem Cells, Graduate School for Medical Science and Engineering, Korea Advanced Institute of Science and Technology

2011年 5月31日
The Rate of Cancer Progression and Metastasis is Determined by the Tumor Microenvironment
Raghu Kalluri 教授
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School

2011年 2月 9日
Angiogenesis Inhibitors in Cancer: Lessons and Surprises
Donald M. McDonald 教授
Department of Anatomy, University of California SanFrancisco

2010年 9月 8日
リンパ管形成における転写ネットワークの役割
渡部 徹郎 准教授
東京大学大学院 医学系研究科 分子病理学

2010年 3月18日
Novel basic and therapeutic insights in angiogenesis
Peter Carmeliet 教授
Vesalius Research Center (VRC)

2010年 2月25日
新規がん治療法として抗血管新生療法の意義
Robert S. Kerbel 教授
Sunnybrook Health Sciences Centre, Toronto University

2010年 2月22日
VEGF receptor signal transduction
Claesson-Welsh L 教授
Uppsala University

2009年10月13日
Inflammation and Cancer: Molecular Targets and Opportunities
Raymond N. DuBois 教授
Vice President, M.D. Anderson Cancer Center

2009年 2月18日
Role of VEGF and other mediators in tumor angiogenesis
Napoleone Ferrara 先生
Fellow, Genentech Inc.

2008年 7月 3日
生理活性資質の受容体:遺伝子から臨床応用へ
横溝 岳彦 教授
九州大学 医学研究院 医化学分野

2008年 6月30日
Pharmacogenomics: From SNP Discovery to Drug Therapy
Kathleen M. Giacomini 教授
Department of Biopharmaceutical Sciences School of Pharmacy, University of California San Francisco

2008年 6月20日
顎顔面および心血管系の発生を制御するシグナル経路
栗原 裕基 教授
東京大学大学院 医学系研究科 代謝生理化学

2008年 2月 8日
Ageing and the Hepatic Microvascular System
Robert S. McCuskey 教授
Professor Emeritus of Cell Biology and Anatomy, Pediatrics and Physiology, College of Medicine, University of Arizona

2005年11月28日
VEGFとその受容体による血管新生の分子機構
渋谷 正史 教授
東京大学 医科学研究所 腫瘍抑制分野

2004年11月24日
Roles of TRPV1 in Gastrointestinal function
Peter Holzer 教授
Department of Experimental and Clinical Pharmacology, Medical University of Graz, Austria

2004年10月22日
リンパ管新生の病態への関与と新しい治療法の開発
久保 肇 准教授
京都大学大学院 医学研究科

輪読会

番号 タイトル 雑誌 巻 頁 担当
1 Notch Signaling in Development and Cancer Endocrine Reviews 2007,Vol28(3):p339- 鎌田(腎) 磯野
2 Cancer and The Chemokine Network NATURE Rev.Cancer 2004,Vol.4.July,p540- 加藤(外)
3 Endothelial/Pericyte Interactions Circulation Research 2005,Vol.97 p512- 鎌田(外)
4 Common mechanisms of nerve and blood vessel wiring NATURE 2005,Vol.436 No.14, p193- 中谷
5 Endogenous Stimulators and Inhibitors of Angiogenesis in Gastrointestinal Cancers:Basic Science to Clinical Application Gastroenterology 2005,Vol.129.p2076-2091 阿江
6 Animal modeles in endometriosis research Human Reproduction Update 2006,Vol.12,No.5.p641-649 沼尾
7 Commom and unique mechanisims regulate fibrosis in various fibroproliferative diseases JCI 2007,Vol.117,No.3.p524- 加藤(循)
8 Infection disease,the innate immune response,and fibrosis JCI 2007,Vol.117,No.3.p530- 加藤(フ)
9 Models of liver fibrosis:exploring the dynamic nature of inflammation and repair in a solid organ JCI 2007,Vol.117,No.3.p539- 藤田
10 Systemic sclerosis:a prototypic multisystem fibrotic disorder JCI 2007,Vol.117,No.3.p557- 鈴木
11 ECM remodeling in hypertensive heart disease JCI 2007,Vol.117,No.3.p568- 畑中
12 The role of CXC chemokines in pulmonary fibrosis JCI 2007,Vol.117,No.3.p549- 細野
13 Liver fibrosis JCI 2007,Vol.115,No.2.p-209 南野
14 The SDF-1-CXCR4 signaling pathway:a molecular hub modulating neo-angiogenesis TRENDS in Immunology 2007,Vol.28,No.7.p299- 松井
15 Cancer Interaction with the Bone Microenvironment A Workshop of the National Lnstitutes of Health Tumor Microenvironment Study Section American Journal of Pathology 2006,Vol.168,No.5.p1405- 磯野
16 Angiogenesis:an organising principle for drug discovery? Nature reviews 2007,Vol.6.p273- 黒坂
17 Macrophage Responses to Hypoxia Implications for Tumor Progression and Anti-Cancer Therapies AJP 2005,Vol.167,No.3.p627- 加藤(外)
18 A microenvironmental model of carcinogenesis Nature reviews Cancer AOP,published online 6 dec 2007 鎌田(外)
19 Illuminating the metastatic process Nature reviews Cancer 2007,Vol.7.p737- 中谷
20 Building better magic bullets-improving unconjugated monoclonal antibody therapy for cancer Nature reviews Cancer 2007,Vol.7.p701- 沼尾
21 The tumour microenvironment as a target for chemoprevention Nature reviews Cancer 2007,Vol.7.p139- 阿江
22 The Multiple Languages of Endothelial Cell-to-Cell Communication Arterioscler.Thromb.Vasc.Biol 2007,Vol.26.p1431- 加藤(循)
23 Pathobiology of transforming growth factorβ in cancer, fibrosis and immunologic disease, and therapeutic considerations Laboratory Investigation 2008,Vol.87.p1077- 川村
24 Molecular regulation of angiogenesis and lymphangiogenesis Nature reviews Mol cell biol 2007,Vol.8(6).p464-- 細野
25 The role of myeloid cells in the promotion of tumour angiogenesis Nature reviews Cancer 2008,Vol.8.p618-- 鈴木
26 Cancer stem cells in solid tumours:accumulating evidence and unresolved questions Nature reviews Cancer 2008,Vol.8.p755-- 畑中
27 FLT1 and its ligands VEGFB and PIGF:drug targets for anti-angiogenic therapy? Nature reviews Cancer 2008,Vol.8.p942-- 藤田
28 Insulin and insulin-like growth factor signalling in neoplasia Nature reviews Cancer 2008,Vol.8.p915- 鎌田(腎)
29 Metastasis: from dissemination to organ-specific colonization Nature reviews Cancer 2009,Vol.9.p274- 鎌田(外)
30 Reviews in basic and clinical Gastroenterology Gastroenterology 2009,Vol.136p1182- 佐東
31 Microenvironmental regulation of metastasis Nature reviews Cancer 2009,Vol.9.p239- 南野
32 Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nature reviews Cancer 2009,Vol.9.p265- 松井
33 Eicosanoids and Cancer Nature reviews Cancer 2010,Vol.10.p181- 荒木
34 Fibrpblast growth factor signalling: from development to cancer Nature reviews Cancer 2010,Vol.10.p116- 大久保
35 Instructine role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors Nature reviews Cancer 2010,Vol.10.p138- 藏重
36 Integrins in angiogenesis and lymphangiogenesis Nature reviews Cancer 2008,Vol.8.p155- 小川
37 Non-germline genetically engineered mouse models for translational cancer research Nature reviews cancer 2010,Vol.10.p470- 川村
38 Cancer as an overhealing wound:an old hypothesis revisted Nature reviews Molecullar cell biology 2008,Vol.9.p628- 細野
39 Control of vascular morphogenesis and homeostasis through the sngiopoietin-Tie system Nature reviews Molecullar cell biology 2009,Vol.10.p165- 畑中
40 Sodium sensing in the interstitium and relationship to hypertension Current Opinion in Nephrology and Hypertension 2010,Vol.19:385-392 藤田
41 Lymphangiogenesis: Molecular Mechansisms and Future Promise Cell February ,2010:460-476 鎌田(腎)
42 Tissue remodelling though branching morphogenesis Nature reviews Molecullar cell biology 2009,Vol.10.p831- 大庭
43 Targeting the tumour vasculature: insights from physiological angiogenesis Nature reviews Cancer 2010,Vol.10:505-514 沖崎
44 Mechanotransduction in vascular physiology and atherogenesis Nature reviews Molecullar cell biology 2009,Vol.10.p53- 吉川
45 Contribution of platelets to tumour metastasis Nature reviews Cancer 2011,Vol.11:123-134 小川
46 Lymphatics in Ldiopathic Pulmonary Fibrosis:New Insights into an Old Disases Lymphatic Research and Biology 2009,Vol.7,No.4:197-203 松井
47 Epithelial-to-Mesenchymal Transitions in the Liver Hepatology 2009,Vol.50,(6):2007-2013 南野
48 Novel roles for Slits and netrins:axon guidance cues as anticancer targets? Nature reviews Cancer 2011,Vol.11:188-197 佐東
49 Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases Nature reviews Drug discovery 2010,Vol.9:107-115 藏重
50 Macrophage Diversity Enhances Tumor Progression and Metastasis Cell 2010,vol.141,April 2 大久保
51 Mast cell modulation of vascular and lymphatic endothelium BLOOD 2011,Vol118:5383-5393 細野
52 Lymphatic and interstitial flow in the tumour microenvironmrnt: linking mechanobiology with immunity Nature reviews Cancer 2012,Vol.12:210-219 川村
53 Biological Basis of Therapeutic Lymphangiogenesis Circulation 2011,Vol.123(12):1335-1351 畑中
54 Lymphatics in Lung Disease Ann N Y Acad Sci 2008,Vol.1131:195-202 天野
55 MicroRNA regulation by RNA-binding proteins and its imp;ications for cancer Nature reviews Cancer 2011,Vol.11:644-656 藤田
56 Myeloid-derived suppressor cells as regulators of the immune system Nature reviews immunol 2009,Vol.9(3):162-174
57 Cancer immunotherapy via dendritic cells Nature reviews Cancer 2012,Vol.12(4):265-277 高橋
58 Dynamic niches in the origination and differentiation of haematopoietic stem cells Nature reviews Molecular cell biology 2012,Vol.12(10):643-655 松田
59 Combining immunotherapy and tageted therapies in cancer treatment Nature reviews Cancer 2012,Vol.12(4):237-251 鎌田(腎)
60 Controlling escape from angiogenesis inhibitors Nature reviews Cancer 2012,Vol.12(10):699-709 沖崎
61 Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases Nature reviews Drug discovery 2011,Vol.10:417-426 大庭
62 Basic principles of tumor-associated regulatory T cell biology TRENDS in Immunology 2013.Vol34(1):33-40 関口
63 Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity Cancer Immunol Immunother 2010,Vol.59:593-1600 高橋
64 Myeloid-Derived Suppressor cells:Linking Inframmation and Cancer The Journal of Immunology 2009,Vol.182(8):4499-4506 高橋